Bioactive Metabolites from Microorganisms

Selected Papers from the 2nd International Symposium on New Bioactive Metabolites from Microorganisms, Ge (Progress in Industrial Microbiology) by M. E. Bushell

Publisher: Elsevier Science Ltd

Written in English
Published: Pages: 428 Downloads: 367
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  • Biotechnology,
  • Food & beverage technology,
  • Science/Mathematics

Edition Notes

ContributionsU. Grafe (Editor)
The Physical Object
Number of Pages428
ID Numbers
Open LibraryOL10261208M
ISBN 100444880518
ISBN 109780444880512

Microorganisms are rich sources of bioactive compounds, and some of which have pharmacological interests. Examples of drugs from microorganisms are acarbose and voglibose (antidiabetic drugs), lovastatin (cholesterol lowering agent), and ciclosporin (an immunosuppressant drug). In addition, recent studies related to the ecological roles of microbiota associated with their host revealed their. Even the bacteria occurring in the human microbiome produce potent antibiotics, and thus potentially are an untapped resource for novel compounds, potentially with new activities. This review highlights examples of bacteria that should be considered new sources of natural products, including anaerobes, pathogens, and symbionts of humans. The biocontrol potential of agriculturally important microorganisms is mostly attributed to their bioactive secondary metabolites. However, low shelf life of many potential agriculturally important microorganisms impairs their use in agriculture and adoption by farmers.   These bacteria are capable of creating new bioactive metabolites from the foods we eat. For example, many plant-based polyphenolics from our diet are absorbed soon after ingestion, but others are acted upon by intestinal bacteria and add to the diversity of biologically-active compounds circulating in our blood stream.

The bioactive secondary metabolites produced by microorganisms is reported to be aro of wh are produced by actinomycetes,thus representing 45% of all bioactive microbial metabolites discovered (Berdy ). Among actinomycetes, approximately 7, compounds are produced by Streptomyces species (Berdy ).   Testing the inhibition activity of these compounds against a selected pathogenic microorganisms (Bacteria, Candida, Dermatophytes and other fungi). Most recent publications on bioactive metabolites by fungi Last decade several published papers on this aspect: For Examples Anke et al. (, ) from Germany Lindquist et al. (, During the research for bioactive secondary metabolites from microorganisms, the endophytic fungi Aspergillus fumigatus sp. isolate R7 was found to produce a set of promising bioactive compounds () after its large scale fermentation, wor-king up and purification using a series of chromatographic techniques. Structural.   Get this from a library! Bioactive metabolites from microorganisms: selected papers from the 2nd International Symposium on New Bioactive Metabolites from Microorganisms, Gera, GDR, May , [M E Bushell; U Gräfe;].

Both bacteria and fungi are now the target of biomedical study, and fascinating reports of novel metabolites are becoming more and more common. Bacterial samples from coastal sediments, when grown under saline conditions, have yielded new antibiotics, antitumor, and anti-inflammatory compounds (Pathirana et al., ; Trischman et al., a, b). Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates Nat Protoc. ;3(12) doi: /nprot Authors Sherif S Ebada 1, Ru Angelie Edrada, Wenhan Lin, Peter Proksch. Affiliation 1 Institut für. Secondary metabolites have been the focus of research as compared to primary metabolites due to their conferred biological effects on other microorganisms [2 James R. Establishment of adventitious root co-culture of Ginseng and Echinacea for the production of secondary metabolites. Journal of Natural Products (ACS Publications) nd Invitro Antibacterial Activity of Coral Reef Associated Bacteria and Optimization of Bioactive Metabolite Production S. Bharathi*1, Nithya B 1, Saravanan D, Radhakrishnan M2, Balagurunathan R3 1Department of Microbiology, Sri Sankara Arts & Science College, Kanchipuram – .

Bioactive Metabolites from Microorganisms by M. E. Bushell Download PDF EPUB FB2

Bioactive Secondary Metabolite of Microorganisms (Progress in Industrial Microbiology) 1st Edition by Vladimir Betina (Author) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both Cited by: 4. Aging research aims at developing interventions that delay normal aging processes and some related pathologies.

Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of.

small molecular secondary metabolites of microorganisms, usually exhibits some kinds of biological activities, and these compounds, the bioactive secondary microbial. The discovery of new bioactive microbial metabolites: Screening and identification. In Bioactive Metabolites from Microorganisms, Ed.

Bushell ME, Grafe U. Elsevier, Amsterdam ()Cited by: Endophytic fungi have been recognized as a novel source of bioactive secondary metabolites with diverse biological activities such as novel antibiotics, antimycotics, immunosuppressant, anticancer.

Essentially, these compounds play an important role in establishing inter-kingdom interactions. In the last few decades, researchers have explored many types of microbes for bioactive metabolites having pharmacological properties.

Microorganisms are known as the potential source for antioxidants, vitamins, antibiotics and enzymes. Losses in crops caused by plant pathogenic bacteria and parasitic nematode are increasing because of a decrease in efficacy of traditional management measures.

There is an urgent need to develop nonchemical and ecofriendly based management to control plant diseases. A potential approach of controlling plant disease in the crops is the use of biocontrol agents and their secondary metabolites.

Marine organisms are involved in a variety of bioactive metabolites. They manifest a great variety of biological activity. The increasing desire for medicine to be able to manage new diseases that are resistant to strains of microorganisms seemed to arouse unconventional. Introduction 3 Marine Bacteria and Fungi 5 Marine.

That is why it is very important to identify the organisms that produce bioactive secondary metabolites, and to be able to structure a plan of use and preservation of those species that represent a potential source for new drug development, especially those obtained from bacteria, because of their own cultivation characteristics, have attracted.

Bioactive secondary metabolites play a crucial role during the interactions within such microbial communities, and may be related to different mechanisms, like competition for. However, the question of why microorganisms make all these metabolites remains unanswered. Little is known about the natural role of these important compounds.

They have, therefore, been termed “secondary metabolites” so as to distinguish them from the primary metabolites of the cell that are known to be essential for growth of the by: 4.

His major research interests are the investigation and development of bioactive substances derived from marine organisms and their application as cosmeceuticals and nutraceuticals. Professor Kim is the current editor-in-chief of the Korean Journal of Marine Bioscience and Biotechnology.

He has authored over research papers, holds 72 patents. Microorganisms are ubiquitous, can be easily cultivated in the laboratory, and serve as sources of novel bioactive compounds in a sustainable manner.

Metabolites have been used neutraceutically and pharmaceutically for the treatment of various diseases. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches.

It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for. there are bacteria, fungi, microalgae, and symbi-otic microorganisms.

More than 20 bioactive metabolites produced by marine microorganisms have been reported, and almost 10 are derived from actinomycetes, mainly of Streptomyces species (Berdy, ). Most of these metabolites.

In particular, marine bacteria attract attention with their ability to synthesize structurally diverse classes of bioactive secondary metabolites with high biotechnological potential.

The focal theme of this book is to highlight the potential of employing biosynthesized secondary metabolites (SMs) from agriculturally important microorganisms for management of notorious phytopathogens, as a substitute of the currently available whole organism formulations and also as alternatives to hazardous synthetic pesticides.

Introduction. Living organisms are a huge source for a variety of unusual secondary metabolites. The bulk of these metabolites has been found in plants along with the involvement of microorganism (Hadjithomas et al., ).These bioactive compounds are mainly derived from bacteria residing in internal tissues of plants and there are several genus involved in the production of.

Bioactive secondary metabolites produced from Antarctic and Arctic microorganisms The survival of microorganisms in the Antarctic and Arctic conditions of life requires of the relevant genera and species special adaptability and resistance against stressors such as lack of substrate, UV-radiation, low temperatures in a long.

The secondary metabolite-producing microorganisms synthesize these bioactive and complex molecules at the lag phase and stationary phase of their growth.

However, regarding actinomycetes and Streptomyces especially, secondary metabolites can be produced at exponential, stationary, and death phases [ 6, 7 ]. Lycium minutifolium J.

Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach pain, meteorism, intestinal disorders, stomach ailments, and other severe problems including prostate cancer and stomach cancer. From the EtOAc extract of L. minutifolium bark five known metabolites were isolated using chromatographic techniques.

Bioactive Metabolites from Microorganisms: Selected Papers from the 2nd International Symposium on New Bioactive Metabolites from Microorganisms, Ge (Progress in Industrial Microbiology) (v.

27) by M. Bushell (Author), U. However, drug development from coral-derived microorganisms has been hampered due to only a minor number of microbes being able to be maintained in laboratory conditions [24,].

Furthermore, most of the biosynthetic gene clusters expressing novel bioactive metabolites remain silent or cryptic under laboratory culture conditions [,]. Preparation of high production microorganisms 2. Genetic manipulation of secondary metabolites producers 3.

Bioengineering of secondary metabolites 4. Secondary metabolites: from metabolic engineering to synthetic biology/Metabolomics for secondary metabolites.

Section C. Obtaining new bioactive secondary metabolites 1. Isolation from. Keywords:Bioactive compounds, endophytes, host plants, isolation, purification, secondary metabolites. Abstract: Endophytes are the microorganisms that occur within the tissues of the plants without causing any noticeable symptoms and diseases to the host.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

(). Bioactive Metabolites Produced by Microorganisms Collected in Antarctica and the Arctic. Biotechnology & Biotechnological Equipment: Vol. 25, WHO WE ARE AND WHAT WE ACHIEVED, pp. Consequently, the application of the producing bacteria or the bioactive compounds might cause adverse effects on the organisms to be treated (e.g., humans, animals, or plants) or, in the case of aquaculture, negatively affect the other organisms involved in fish or shellfish culture such as algae or live prey (e.g., rotifers and Artemia sp.

Biofuels, metabolites, and biofertilizers. Few Chemicals, Enzymes and other Bioactive Molecules. Vaccines and other Antibiotics to kill or retard the growth of disease-causing microbes. Let us know in detail about the role of microbes in industrial products.

Microbes in Industrial Products. The isolation and extraction of novel bioactive secondary metabolites from marine microorganisms have a biomedical potential for future drug discovery as the oceans cover 70% of the planet's surface and life on earth originates from sea.

Wide range of novel bioactive secondary metabolites exhibiting pharmacodynamic properties has been isolated. The microorganisms such as endophytes may be very interesting for biotechnological production of bioactive substances as medicinally important agents.

Therefore the aim of this review is to briefly characterize endophytes and summarize the structuraly different bioactive secondary metabolites produced by endophytic microorganisms as well as.1. Bioactive Metabolites of Marine Algae, Fungi and Bacteria 1 1. Introduction 1 2.

Secondary Metabolites of Marine Algae 2 3. Bioactive Metabolites 2 Brominated phenols 2 Brominated oxygen heterocyclics 3 Nitrogen heterocyclics 4 Kainic acids 4 Guanidine derivatives 5 Phenazine derivatives 6 Amino acids and amines 7.Title:Bioactive Secondary Metabolites from Endophytic Fungi VOLUME: 27 ISSUE: 11 Author(s):Elena Ancheeva, Georgios Daletos* and Peter Proksch* Affiliation:Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, DüsseldorfInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf.